Nat Rev Drug Discov. 2002 May;1(5):375-82.
Potential cardioprotective actions of no-releasing aspirin.
Wallace JL, Ignarro LJ, Fiorucci S. Department of Pharmacology & Therapeutics, University of Calgary, Calgary, Alberta, T2N 4N1 Canada.
The use of low doses of aspirin on a daily basis has increased greatly in the past 20 years, based on observations that it can significantly reduce the risk of heart attacks and strokes. However, aspirin can also cause severe damage to the stomach. A modified version of aspirin that releases nitric oxide has been developed that seems to offer important advantages over its 103-year-old parent--namely, improved protection for the heart without the unwanted effects on the stomach.
