Proc Soc Exp Biol Med. 2000 Dec;225(3):200-6.
Nitric oxide donors.
Yamamoto T, Bing RJ. Department of Experimental Cardiology, Huntington Medical Research Institutes, Pasadena, California 91101, USA.
Nitric oxide (NO) donors are pharmacologically active substances that release NO in vivo or in vitro. NO has a variety of functions such as the release of prostanoids, inhibition of platelet aggregation, effect on angiogenesis, and production of oxygen free radicals. This report discusses the chemical and pharmacological characteristics of NO donors, their effect on platelet function and cyclooxygenase, their cardiac action including myocardial infarction, and release of superoxide anions. This review stresses NO tolerance and the effect of NO donors on angiogenesis in myocardial infarction and in solid tumors.
